Cremophor RH 40 (PEG-40 Hydrogenated Castor Oil) is anon-ionic solubilizer and emulsifying agent obtained by reacting hydrogenated castor oil with ethylene oxide. It conforms to the current Ph. Eur./USP requirements.Used to solubilize ethereal oils, perfume compositions, vitamins, and hydrophobic active substances in aqueous- alcoholic and purely aqueous solutions. The finished preparations are particularly stable. Cremophor RH 40shows little tendency to foaming, which is particularly important for solutions in aqueous ethanol. Further foam suppression can be obtained by adding a small amount of defoamer.
The undiluted Cremophor RH 40is white to yellowish soft or flowing pastes at 23 °C and has the outstanding feature that its aqueous solutions have a very faint odor. It forms nearly clear solutions in water, ethanol, and isopropanol, and in essential oils and other hydrophobic compounds, e.g. vitamins and alpha-bisabolol. Can be mixed with other Cremophor grades. With gentle heating, forms clear mixtures with fatty acids and fatty alcohols.
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